Around 1950 BC, in the reign of Mentuhotep III, an officer named Hennu made one or more voyages to Punt. In the 15th century BC, Nehsi conducted a very famous expedition for Queen Hatshepsut to obtain myrrh; a report of that voyage survives on a relief in Hatshepsut's funerary temple at Deir el-Bahri. Several of her successors, including Thutmoses III, also organized expeditions to Punt.

Iranian and Scythian Connections

The expansion of Scythian Iranian cultures stretching from the Hungarian plain and the Carpathians to the Chinese Kansu Corridor and linking Iran, and the Middle East with Northern India and the Punjab, undoubtedly played an important role in the development of the Silk Road. Scythians accompanied the Assyrian Esarhaddon on his invasion of Egypt, and their distinctive triangular arrowheads have been found as far south as Aswan. These nomadic peoples were dependent upon neighbouring settled populations for a number of important technologies, and in addition to raiding vulnerable settlements for these commodities, also encouraged long distance merchants as a source of income through the enforced payment of tariffs. Soghdian Scythian merchants were in later periods to play a vital role in the development of the Silk Road.

British Tin

Britain had large reserves of tin in the areas of Cornwall and Devon in what is now southwest England. By around 1600 BC the southwest of Britain was experiencing a trade boom, as mined British tin was being exported across Europe. When the Bronze Age gave way to the Iron Age around the Mediterranean the shipping of tin ended between 1200 and 1100 BC. No land route has ever been found between ancient Britain and Mediterranean civilizations.

Chinese and Central Asian Contacts

From the 2nd millennium BC nephrite jade was being traded from mines in the region of Yarkand and Khotan to China. Significantly, these mines were not very far from the lapis lazuli and spinel ("Balas Ruby") mines in Badakhshan and, although separated by the formidable Pamir mountains, routes across them were, apparently, in use from very early times.

The Tarim mummies, Chinese mummies of an Indo-European type, have been found in the Tarim Basin, such as in the area of Loulan located along the Silk Road 200 kilometers east of Yingpan, dating to as early as 1600 BC and suggesting very ancient contacts between East and West. It has been suggested that these mummified remains may have been the work of the ancestors of the Tocharians whose Indo-European language remained in use in the Tarim Basin (modern day Xinjiang) of China until the 8th century CE.

Some remnants of what was probably Chinese silk have been found in Ancient Egypt from 1070 BC. Though the originating source seems sufficiently reliable, silk unfortunately degrades very rapidly and we cannot double-check for accuracy whether it was actually cultivated silk (which would almost certainly have come from China) that was discovered or a type of "wild silk," which might have come from the Mediterranean region or the Middle East.

Following contacts of metropolitan China with nomadic western and northwestern border territories in the 8th century BC, gold was introduced from Central Asia, and Chinese jade carvers began to make imitation designs of the steppes, adopting the Scythian-style animal art of the steppes (descriptions of animals locked in combat). This style is particularly reflected in the rectangular belt plaques made of gold and bronze with alternate versions in jade and steatite.

Persian Royal Road

By the time of Herodotus (c. 475 BC) the Persian Royal Road ran some 2,857 km from the city of Susa on the lower Tigris to the port of Smyrna (modern Izmir in Turkey) on the Aegean Sea. It was maintained and protected by the Achaemenid empire (c.700-330 BC) and had postal stations and relays at regular intervals. By having fresh horses and riders ready at each relay, royal couriers could carry messages the entire distance in 9 days, though normal travellers took about three months. This Royal Road linked into many other routes. Some of these, such as the routes to India and Central Asia, were also protected by the Achaemenids, encouraging regular contact between India, Mesopotamia and the Mediterranean. There are accounts in Esther of dispatches being sent from Susa to provinces as far out as India and Cush during the reign of Xerxes (485-465 BC).

Roman and Egyptian transatlantic voyages - In 1975 two intact amphorae were recovered from the bottom of Guanabara Bay, near Rio de Janeiro, Brazil. In 1981 archeologist Robert Marx discovered thousands of pottery fragments in the same locality, including 200 necks from amphorae. The amphorae have been shown to be of Roman make, from the 2nd Century BC. Also, tests done on internal tissue samples from ancient Egyptian mummies have revealed traces of chemicals only found in the Americas in antiquity, such as tobacco and coca. Because the samples taken from sundry Egyptian mummies were of internal tissues, the likelihood for contamination is smaller.

Hellenistic conquests

The first major step in opening the Silk Road between the East and the West came with the expansion of Alexander the Great deep into Central Asia, as far as Ferghana at the borders of the modern-day Xinjiang region of China, where he founded in 329 BC a Greek settlement in the city of Alexandria Eschate "Alexandria The Furthest", Khujand (also called Khozdent or Khojent - formely Leninabad), in the state of Tajikistan.